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You are here:Home » Biochemicals » Biochem-Apoptosis » SMI-4a ((5E/Z)-methylene]-2,4-thiazolidinedione)

SMI-4a ((5E/Z)-methylene]-2,4-thiazolidinedione)


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Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.
Catalog #045305
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
CAS Number327033-36-3
Molecular FormulaC11H6F3NO2S
Molecular Weight273.2
Purity>95% (NMR)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names(5E/Z)-methylene]-2,4-thiazolidinedione

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