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You are here:Home » Biochemicals » Biochem-Apoptosis » Swinholide A

Swinholide A


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Cell permeable dimeric dilactone macrolide
Cytotoxic compound
Specific actin filament (F-actin) inhibitor. Disrupts the actin cytoskeleton by sequestering actin dimers and rapidly severing actin filaments (F-actin)
Depolymerizes actin filaments (F-actin)
Apoptosis inducer
Alterates the actin cytoskeleton of GH4 cells and inhibits insulin-increased prolactin gene transcription
Catalog #045320
SolubilitySoluble in ethanol, methanol, DMSO, acetone or ethyl acetate.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number95927-67-6
Molecular FormulaC78H132O20
Molecular Weight1389.9
SourceTheonella swinhoei
Purity97% (HPLC)
FormSupplied as a colorless oil
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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