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You are here:Home » Growth Factors, Cytokines » Growth Factors-TNF » TNF-alpha, Soluble, Recombinant, Human (ACRP30headless:TNF-alpha, ACRP30headless:TNFSF2, ACRP30headless:Tumor Necrosis Factor-alpha)

TNF-alpha, Soluble, Recombinant, Human (ACRP30headless:TNF-alpha, ACRP30headless:TNFSF2,
ACRP30headless:Tumor Necrosis Factor-alpha)

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Specifications

Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MegaTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30.
Catalog #045341
Biological ActivityActivates human and mouse TNF-R1 and TNF-R2.
SequenceThe extracellular domain of human TNF-alpha (aa 85-233) is fused at the N-terminus to human ACRP30headless (aa 16-108) and a FLAG®-tag.
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.
Molecular Weight~34kD (SDS-PAGE)
SourceHuman, HEK 293 cells
Purity>95% (SDS-PAGE)
Concentration0.1mg/ml
FormSupplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
SpecificityBinds to human and mouse TNF-R1 and TNF-R2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesACRP30headless:TNF-alpha, ACRP30headless:TNFSF2, ACRP30headless:Tumor Necrosis Factor-alpha


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