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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -TRB-3 (Tribbles Homolog 3, Neuronal Cell death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappaB)

Anti -TRB-3 (Tribbles Homolog 3, Neuronal Cell death-inducible Putative Kinase, SINK,
p65-interacting Inhibitor of NF-kappaB)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Tribbles homolog 3 (TRB-3) is a pseudokinase, shown to act as a potent negative regulator of PPAR?, a master regulator of adipocyte differentiation, and to control adipogenesis. It disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. It interacts also with the NF-kappaB transactivator p65 RELA. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells.
Catalog #045373
ApplicationsSuitable for use in ELISA, Immunohistochemistry, Western Blot
Recommended DilutionOptimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration1mg/ml
FormSupplied as a liquid in 0.2um-filtered PBS, pH 7.4. No preservative added.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa 112-125 (A112RLPPHKHVARPTE125) of human TRB-3.
SpecificityRecognizes human TRB-3. Detects a band of ~28kD by Western blot (predicted 39kD).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesTribbles Homolog 3, Neuronal Cell death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappaB


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