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You are here:Home » Biochemicals » Biochem-Inflammation » WY-14643 (Pirinixic acid, NSC 310038, BRN 0759945, ((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio) acetic acid)

WY-14643 (Pirinixic acid, NSC 310038, BRN 0759945,
((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio) acetic acid)


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Potent peroxisome proliferator-activated receptor (PPARalpha) activator. Activates also PPARgamma but not PPARdelta.
Potent anti-hypercholesterolemic agent.
Hypolipidemic compound. Lipogenesis inducer.
Tumor promoter.
Causes increased cell proliferation and decreased apoptosis.
Anti-inflammatory. Inhibits NF-kappaB transcriptional activity and decreases the inflammatory response by reducing the production of inflammatory cytokines (TNF-alpha, IL1beta). Reduces oxidative stress.
Increases fatty acid oxidation.
Directly affects insulin signaling. Increases glucose uptake.
Catalog #045394
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
CAS Number50892-23-4
Molecular FormulaC14H14ClN3O2S
Molecular Weight323.8
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPirinixic acid, NSC 310038, BRN 0759945, ((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio) acetic acid

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