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You are here:Home » Biochemicals » Biochem-Apoptosis » Z-VAD-FMK (Cell permeable) (Z-VAD(OMe)-FMK, pan-Caspase Inhibitor, Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone, Benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone)

Z-VAD-FMK (Cell permeable) (Z-VAD(OMe)-FMK, pan-Caspase Inhibitor,
Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone,
Benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone)

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Specifications

Cell-permeable, non-selective broad-spectrum caspase inhibitor. Binds irreversibly to the catalytic site of caspase proteases.
The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability.
Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction.
Decreases proteasome activity.
Potent inhibitor of caspase-1 activation in NLRP3-induced cells.
Used in apoptosis and inflammasome studies.
Catalog #045397
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 3 years after receipt when stored at -20°C.
CAS Number187389-52-2,634911-81-2
Molecular FormulaC22H30FN3O7
Molecular Weight467.5
Purity>95% (HPLC)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesZ-VAD(OMe)-FMK, pan-Caspase Inhibitor, Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone, Benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone


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