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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -AS160, phosphorylated (pT642) (TBC1D4, AS160, DKFZp779C0666, TBC1 domain family member 4, Akt substrate of 160kD)

Anti -AS160, phosphorylated (pT642) (TBC1D4, AS160, DKFZp779C0666, TBC1 domain family
member 4, Akt substrate of 160kD)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
AS160 is a Rab GTPase-activating protein (GAP) that is part of a subfamily of Rab GAPs that contain a conserved TBC1 (Tre-2/Bub2/Cdc16) domain (1). It is a negative regulator of GLUT4 vesicle translocation to the plasma membrane. The phosphorylation of TBC1D4 suppresses its GAP activity, thereby triggering docking of GLUT4 vesicles (2). AS160 is phosphorylated at multiple sites including Threonine 642. Insulin and IGF-1 induce 14-3-3 binding to AS160 mainly via phospho-Threonine 642 (3).
Catalog #045531
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No13C11
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, sodium azide, BSA, glycerol.
PuritySupernatant
ImmunogenPhospho specific peptide corresponding to residues surrounding Threonine 642 of human AS160.
SpecificityRecognizes human AS160.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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