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You are here:Home » Antibodies » Abs to Signal Transduction » Anti -Periplakin (PPL, KIAA0568, MGC134872, Periplakin, 190 kDa paraneoplastic pemphigus antigen, 195kD cornified envelope precursor protein)

Anti -Periplakin (PPL, KIAA0568, MGC134872, Periplakin, 190 kDa paraneoplastic pemphigus
antigen, 195kD cornified envelope precursor protein)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH
Periplakin is a component of desmosomes and the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane, and its C-terminus interacts with intermediate filaments. Through its rod domain, Periplakin forms complexes with envoplakin. It may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with Periplakin, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling (1).
Catalog #045557
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-10,000
Immunohistochemistry: 1:50-100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No13C96
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, sodium azide, BSA, glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues in human Periplakin.
SpecificityRecognizes human Periplakin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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