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You are here:Home » Antibodies » Abs to Topoisomerases » Anti -Topoisomerase 1 (TOP1, TOPI, DNA topoisomerase 1, DNA topoisomerase I)

Anti -Topoisomerase 1 (TOP1, TOPI, DNA topoisomerase 1, DNA topoisomerase I)


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Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IC
Topoisomerase 1 is an enzyme that controls and alters the topologic states of DNA during transcription. It catalyzes the transient breaking and rejoining of a single strand of DNA, which allows the strands to pass through one another, thus altering the topology of DNA (1). Topoisomerase 1 has been further classified into two different families, types IA and IB, depending on whether they form a transient covalent bond with the 5' or 3' end of the broken DNA strand (2). Eukaryotic topoisomerase 1 and 2 can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils (3).
Catalog #045591
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-10,000
Immunocytochemistry: 1:250-500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No13C126
ConcentrationNot determined
FormSupplied as a liquid in PBS, sodium azide, BSA, glycerol.
ImmunogenSynthetic peptide corresponding to residues in human Topoisomerase 1.
SpecificityRecognizes human Topoisomerase 1. Species sequence homology: Mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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