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You are here:Home » Antibodies » Abs to Interferon » Anti -IFN alpha R1 (IFNAR1, FN-alpha-REC, IFNBR, IFRC, Interferon alpha/beta receptor 1)

Anti -IFN alpha R1 (IFNAR1, FN-alpha-REC, IFNBR, IFRC, Interferon alpha/beta receptor 1)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
Interferon alpha receptor 1 (IFN alpha R1) is a class II cytokine receptor that belongs to the type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN alpha R1 is a 135kD signal transducing subunit of the IFN alpha/beta receptor complex (IFN- R) (1). IFN alpha R1 is phosphorylated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN alpha R1 (2).
Catalog #045630
ApplicationsSuitable for use in Western Blot. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000-1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone NoEPR6244
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues in human IFN alpha R1.
SpecificityRecognizes human IFN alpha R1. Species crossreactivity: Mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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