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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -ABCA1 (ATP-binding Cassette Sub-family A Member 1, ATP-binding Cassette Transporter 1, ABC-1, ATP-binding Cassette 1, Cholesterol Efflux Regulatory Protein, ABC1, CERP)

Anti -ABCA1 (ATP-binding Cassette Sub-family A Member 1, ATP-binding Cassette Transporter
1, ABC-1, ATP-binding Cassette 1, Cholesterol Efflux Regulatory Protein, ABC1, CERP)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
Catalog #122792
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Amino Acid SequenceTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDTSMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILHKVFLQ
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM,k
Clone No1H4
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid.
PurityAscites
ImmunogenPartial recombinant corresponding to aa86-185 from human ABCA1 with GST tag (NP_005493). MW of the GST tag alone is 26kD.
SpecificityRecognizes human ABCA1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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