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You are here:Home » Antibodies » Abs to Neuroscience » Anti -ANK1 (Ankyrin-1, Ankyrin 1, ANK-1, Ankyrin-R, Erythrocyte Ankyrin, ANK)

Anti -ANK1 (Ankyrin-1, Ankyrin 1, ANK-1, Ankyrin-R, Erythrocyte Ankyrin, ANK)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IP
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin actin cytoskeleton and therefore play a role in cell motility, proliferation and intercellular contact. Different isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains. Ankyrin 1, the prototype of this family, was first discovered in erythrocytes but has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated with hereditary spherocytosis. Different isoforms of ankyrin 1 have been described. Alternative polyadenylation accounting for the different sized erythrocytic ankyrin 1 mRNAs, has also been reported.
Catalog #123328
ApplicationsSuitable for use in ELISA and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
AA SequenceMWTFVTQLLVTLVLLSFFLVSCQNVMHIVRGSLCFVLKHIHQELDKELGESEDLSDDEETISTRVVRRRVFLKGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No3C3
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenFull length recombinant corresponding to aa1-155 from human ANK1 (AAH30957) with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human ANK1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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