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You are here:Home » Antibodies » Abs to Ion Channel » Anti -CACNA1S (Voltage-dependent L-type Calcium Channel Subunit alpha-1S, Calcium Channel, L Type, alpha-1 Polypeptide, Isoform 3, Skeletal Muscle, Voltage-gated Calcium Channel Subunit alpha Cav1.1, CACH1, CACN1, CACNL1A3)

Anti -CACNA1S (Voltage-dependent L-type Calcium Channel Subunit alpha-1S, Calcium Channel,
L Type, alpha-1 Polypeptide, Isoform 3, Skeletal Muscle, Voltage-gated Calcium Channel
Subunit alpha Cav1.1, CACH1, CACN1, CACNL1A3)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
Catalog #124207
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
AA SequenceCPRVESSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQALGDACQMEPEEVEIMATELLKGREA
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No2C5
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenPartial recombinant corresponding to aa1743-1838 from human CACNA1S (NP_000060) with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human CACNA1S.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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