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You are here:Home » Antibodies » Abs to G Protein Receptors » Anti -CCR2 (C-C Chemokine Receptor Type 2, Chemokine (C-C Motif) Receptor 2, C-C CKR-2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CKR2, CKR2A, CKR2B, CMKBR2, CD192, Monocyte Chemoattractant Protein 1 Receptor, MCP-1-R)

Anti -CCR2 (C-C Chemokine Receptor Type 2, Chemokine (C-C Motif) Receptor 2, C-C CKR-2,
CC-CKR-2, CCR-2, CCR2A, CCR2B, CKR2, CKR2A, CKR2B, CMKBR2, CD192, Monocyte Chemoattractant
Protein 1 Receptor, MCP-1-R)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
CCR2, a Chemokine Receptor, is a regulator of monocyte/macrophage traffickingis and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis (Boring et al., 1998) and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis (Ruth et al., 2001). ESTs have been isolated from liver/spleen and prostate libraries.
Catalog #124487
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
AA SequenceMLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGA
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM,k
Clone No4D12
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenPartial recombinant corresponding to aa1-42 from human CCR2 (NP_000639) with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human CCR2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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