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You are here:Home » Antibodies » Abs to Collagen » Anti -COL1A1 (Collagen alpha-1(I) Chain, Alpha-1 Type I Collagen)

Anti -COL1A1 (Collagen alpha-1(I) Chain, Alpha-1 Type I Collagen)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
COL1A1 is the major component of type I collagen, and the sole component of the collagen located in cartilage. COL1A1 mutations are associated with osteogenesis imperfecta type I, II, III, and IV, Ehlers-Danlos syndrome type I and II, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a skin tumor called dermatofibrosarcoma protuberans. Two COL1A1 transcripts arise from variant polyadenylation signals for this gene.
Catalog #125176
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml
Optimal dilutions to be determined by the researcher.
AA SequenceEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIK
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG3,k
Clone No3G3
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenPartial recombinant corresponding to aa1021-1108 from human COL1A1 (NP_000079.1) with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human COL1A1. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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