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You are here:Home » Antibodies » Abs to Enzymes, Cytochrome » Anti -COX17 (COX17 Homolog Cytochrome C Oxidase Assembly Protein, Cytochrome C Oxidase Copper Chaperone, Human Homolog of Yeast Mitochondrial Copper Recruitment, MGC104397, MGC117386)

Anti -COX17 (COX17 Homolog Cytochrome C Oxidase Assembly Protein, Cytochrome C Oxidase
Copper Chaperone, Human Homolog of Yeast Mitochondrial Copper Recruitment, MGC104397,
MGC117386)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% aa sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.
Catalog #125246
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml
Optimal dilutions to be determined by the researcher.
AA SequenceMPGLVDSNPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No4G2
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenPartial recombinant corresponding to aa1-63 from COX17 (NP_005685) with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human COX17.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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