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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -ICEBERG (Caspase Recruitment Domain-containing Protein 18, Caspase-1 Inhibitor Iceberg, CARD18, UNQ5804/PRO19611)

Anti -ICEBERG (Caspase Recruitment Domain-containing Protein 18, Caspase-1 Inhibitor
Iceberg, CARD18, UNQ5804/PRO19611)

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Specifications

Clone Host Grade Applications
Polyclonal Mouse Affinity Purified B
ICEBERG, an inhibitor of pro-caspase-1 activation, consists essentially of only a CARD. It inhibits generation of IL-1b by interacting with caspase-1 and preventing association with RIP2. The ICEBERG functions as a competitive antagonist of RIP2/pro-caspase-1 interactions and inhibits caspase-1-dependent pro-L-1b secretion in mononuclear cells. ICEBERG is induced by proinflammatory stimuli, suggesting that it may be part of a negative feedback loop.
Catalog #128192
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
AA SequenceMADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEEDPQLASKMGLH
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenFull length human ICEBERG, aa1-90 (NP_067546.1).
SpecificityRecognizes human ICEBERG.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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