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You are here:Home » Antibodies » Abs to Immunoglobulins » Anti -CADM1 (IGSF4, IGSF4A, NECL2, SYNCAM, TSLC1, Cell Adhesion Molecule 1, Immunoglobulin Superfamily Member 4, Nectin-like Protein 2, Spermatogenic Immunoglobulin Superfamily, Synaptic Cell Adhesion Molecule, Tumor Suppressor in Lung Cancer 1, SgIgSF, SynCAM,

Anti -CADM1 (IGSF4, IGSF4A, NECL2, SYNCAM, TSLC1, Cell Adhesion Molecule 1, Immunoglobulin
Superfamily Member 4, Nectin-like Protein 2, Spermatogenic Immunoglobulin Superfamily,
Synaptic Cell Adhesion Molecule, Tumor Suppressor in Lung Cancer 1, SgIgSF, SynCAM,

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Catalog #128355
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
AA SequenceIQRDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMT*
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No1B5
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenPartial recombinant corresponding to aa151-251, from IGSF4 (NP_055148) with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human IGSF4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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