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You are here:Home » Antibodies » Abs to Interleukin » Anti -IL1B (Interleukin-1 beta, IL-1 beta, Catabolin, IL1F2)

Anti -IL1B (Interleukin-1 beta, IL-1 beta, Catabolin, IL1F2)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP IF
IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.
Catalog #128426
ApplicationsSuitable for use in Immunofluorescence, ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionImmunofluorescence: 10ug/ml
Sandwich ELISA: The detection limit is ~10ng/ml as a capture antibody
Optimal dilutions to be determined by the researcher.
Amino Acid SequenceDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No2A8
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenPartial recombinant corresponding to aa170-269 from human IL1B (AAH08678) with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human IL1B.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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