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You are here:Home » Antibodies » Antibodies-Integrin » Anti -ITGB7 (Integrin B7, Integrin beta-7, Gut Homing Receptor beta Subunit)

Anti -ITGB7 (Integrin B7, Integrin beta-7, Gut Homing Receptor beta Subunit)


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Clone Host Grade Applications
Polyclonal Mouse Affinity Purified B
Integrin B7 is a 130kD glycoprotein, also known as integin Bp. It is a member of the Ig superfamily. In association with integrin a4 or aE chain, B7 forms a4/B7 or aE/B7 heterodimer. a4/B7 (CD49d/B7, LPAM-1) is expressed on majority of peripheral lymphocytes, small subsets of thymocytes and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion, some hematopoietic progenitor cells migration. aE/B7 (CD103/B7,aIEL/B7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/B7 complex is thought to play a role in lymphocyte retention via interaction with its lignd E-Cadherin. This antibody has been reported to react with mouse and human B7 integrin and to block B7 integrin-mediated cell adhesion in in vitro and in vivo studies.
Catalog #128645
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenFull length human ITGB7, aa1-798 (NP_000880.1).
SpecificityRecognizes human ITGB7.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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