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You are here:Home » Antibodies » Abs to Enzymes, Demethylase » Anti -JARID1B (KDM5B, PLU1, RBBP2H1, Lysine-specific Demethylase 5B, Cancer/Testis Antigen 31, Histone Demethylase JARID1B, Jumonji/ARID Domain-containing Protein 1B, PLU-1, Retinoblastoma-binding Protein 2 Homolog 1, FLJ10538, FLJ12459, FLJ12491, FLJ16281, FLJ

Anti -JARID1B (KDM5B, PLU1, RBBP2H1, Lysine-specific Demethylase 5B, Cancer/Testis Antigen
31, Histone Demethylase JARID1B, Jumonji/ARID Domain-containing Protein 1B, PLU-1,
Retinoblastoma-binding Protein 2 Homolog 1, FLJ10538, FLJ12459, FLJ12491, FLJ16281, FLJ

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH IF
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Catalog #128679
ApplicationsSuitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 10ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 1ug/ml
Optimal dilutions to be determined by the researcher.
AA SequenceAKRMRAEAMNIKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRSKKATNAVDLYVCLLCGSGN
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No1G10
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenPartial recombinant corresponding to aa231-319 from human JARID1B (NP_006609) with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human JARID1B. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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