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You are here:Home » Antibodies » Abs to Pleckstrin Homology Proteins » Anti -PLEKHO1 (Pleckstrin Homology Domain-containing Family O Member 1, PH Domain-containing Family O Member 1, C-Jun-binding Protein, JBP, Casein Kinase 2-interacting Protein 1, CK2-interacting Protein 1, CKIP-1, Osteoclast Maturation-associated Gene 120 Prote

Anti -PLEKHO1 (Pleckstrin Homology Domain-containing Family O Member 1, PH
Domain-containing Family O Member 1, C-Jun-binding Protein, JBP, Casein Kinase
2-interacting Protein 1, CK2-interacting Protein 1, CKIP-1, Osteoclast
Maturation-associated Gene 120 Prote

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B
CKIP-1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). This protein may function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). It appears to target ATM to the plasma membrane and appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Catalog #131463
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
AA SequenceMMKKNNSAKRGPQDGNQQPAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM,k
Clone No3D5
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in ascites fluid.
PurityAscites
ImmunogenFull length recombinant corresponding to aa1-410 from human PLEKHO1 (AAH10149) with GST tag.
SpecificityRecognizes human PLEKHO1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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