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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -ABCA1 (ATP-binding Cassette Sub-family A Member 1, ATP-binding Cassette Transporter 1, ABC-1, ATP-binding Cassette 1, ABC1, CERP)

Anti -ABCA1 (ATP-binding Cassette Sub-family A Member 1, ATP-binding Cassette Transporter
1, ABC-1, ATP-binding Cassette 1, ABC1, CERP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
ABCA1 (ATP-binding Cassette, Sub-family A, Member 1), also known as ABC1 (ABC Transporter 1) or CERP (Cholesterol efflux regulatory protein), is a member of the family of ATP-binding cassette (ABC) transporters. It is a cAMP-dependent, sulfonylurea-sensitive traffic ATPase, which is located at the plasma membrane and plays a key role in the cellular lipid removal pathway. ABCA1 supports apolipoprotein A-I (APOA1)-mediated cellular efflux of cholesterol and choline-phospholipids into the blood circulation; therefore, ABCA1 defects result in reduced plasma level of high density lipoproteins (HDL) combined with the tissue deposition of cholesteryl esters. Homozygous mutations in ABCA1 are the cause of Tangier disease, which is characterized by the absence of HDL in plasma, hepatosplenomegaly, peripheral neuropathy, and frequently premature coronary artery disease. Noticeably, heterozygous Tangier disease carriers have an approximately 2-fold reduction in HDL level. More commonly, ABCA1 inherited defects are associated with a milder condition, so-called familial hypoalphalipoproteinemia (FHA). FHA patients, similar to Tangier disease patients, demonstrate a very evident decrease of HDL level; however, they lack clinical manifestations.
Catalog #135871
ApplicationsSuitable for use in Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:5000
Immunohistochemistry (Paraffin): 1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenSynthetic peptide corresponding to human ABCA1.
SpecificityRecognizes human ABCA1. Species Crossreactivity: Mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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