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You are here:Home » Antibodies » Abs to Protein Kinases » Anti -ADK (AK, Adenosine kinase)

Anti -ADK (AK, Adenosine kinase)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Adenosine kinase (ATP: adenosine 5-prime-phosphotransferase) is an abundant enzyme in mammalian tissues that catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of ADK could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as antiinflammatory agents. There are 2 ADK transcripts that encode a 345-amino acid form and a 362-amino acid form of the enzyme. These 2 alternately spliced forms differ only at the 5-prime end, where the first four encoded residues of the short form are replaced by 21 residues in the long form. When expressed, both isoforms of the enzyme phosphorylated adenosine with identical kinetics and both required Mg2+ for activity.
Catalog #135884
ApplicationsSuitable for use in ELISA, Western Blot, Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Immunohistochemistry (Paraffin): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant corresponding to human ADK.
SpecificityRecognizes human ADK.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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