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You are here:Home » Antibodies » Abs to Apoptosis » Anti -ARC, CT (Apoptosis Repressor with CARD, Myp, Nucleolar Protein of 30kD, Nop30, NOL3, NOP)

Anti -ARC, CT (Apoptosis Repressor with CARD, Myp, Nucleolar Protein of 30kD, Nop30, NOL3,
NOP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. ARC is phosphorylated by casein kinase II (CK2) and phosphorylation is necessary to prevent apoptosis.
Catalog #135906
ApplicationsSuitable for use in ELISA, Western Blo and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:20,000
Western Blot: 1:500-1:1000
Immunohistochemistry (Paraffin): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human NOL3 at C-Terminal.
SpecificityRecognizes human NOL3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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