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You are here:Home » Antibodies » Abs to Enzymes, Cytochrome » Anti -CYBB (Cytochrome b-245 Heavy Chain, CGD91-phox, Cytochrome b(558) Subunit beta, Cytochrome b558 Subunit beta, gp91-1, gp91-phox, NOX2)

Anti -CYBB (Cytochrome b-245 Heavy Chain, CGD91-phox, Cytochrome b(558) Subunit beta,
Cytochrome b558 Subunit beta, gp91-1, gp91-phox, NOX2)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B IH
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Catalog #136016
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Paraffin): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in Tris,150mM NaCl, pH 8.0, 0.01% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to
SpecificityRecognizes human NOX2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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