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You are here:Home » Antibodies » Abs to RNA Processing » Anti -Dicer (DICER1, DCR1, HERNA, KIAA0928)

Anti -Dicer (DICER1, DCR1, HERNA, KIAA0928)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Ascites E IH FC
Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.
Catalog #136033
ApplicationsSuitable for use in Flow Cytometry, ELISA, Immunohistochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:100-1:1000
ELISA: 1:200
Immunohistochemistry (Paraffin): 1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSera, 0.025% sodium azide, 50% glycerol
PurityAscites
ImmunogenSynthetic peptide corresponding to 1423-1440aa from human
DICER1/Dicer.
SpecificityRecognizes human DICER1/Dicer.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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