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You are here:Home » Antibodies » Antibodies-Enzymes, Phospholipase » Anti -Phospholipase C, gamma 1 (PLCgamma1, PLC-gamma-1, PLCg1, PLC1, NCKAP3, Phospholipase C-II, PLC-II, PLC148)

Anti -Phospholipase C, gamma 1 (PLCgamma1, PLC-gamma-1, PLCg1, PLC1, NCKAP3, Phospholipase


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
PLCg1 hydrolyzes phosphatidylinositol-4,5-bisphosphate to generate inositol-1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG), which are implicated in the mobilization of intracellular Ca2+ and protein kinase C activation, respectively. Unlike other PLC isotypes, the protein contain two src homology (SH) 2 domains and one SH3 domain between the X and Y catalytic domains, and these three domains have been implicated in the regulation of cellular proliferation and growth. The protein also has a key function in the regulation of growth hormone-mediated signalling by negatively regulating Jak2 activation. Human PLCgâ¡ gene maps to the chromosome 20 in the region 20q12-q13.1.
Catalog #136329
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:10,000
Western Blot: 1:500-1:1000
Immunohistochemistry (Paraffin): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human PLCG1.
SpecificityRecognizes human PLCG1. Species Crossreactivity: Mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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