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You are here:Home » Antibodies » Abs to Enzymes, Phospholipase » Anti -Phospholipase C, gamma 1 (PLCgamma1, PLC-gamma-1, PLCg1, PLC1, NCKAP3, Phospholipase C-II, PLC-II, PLC148)

Anti -Phospholipase C, gamma 1 (PLCgamma1, PLC-gamma-1, PLCg1, PLC1, NCKAP3, Phospholipase
C-II, PLC-II, PLC148)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
PLCg1 hydrolyzes phosphatidylinositol-4,5-bisphosphate to generate inositol-1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG), which are implicated in the mobilization of intracellular Ca2+ and protein kinase C activation, respectively. Unlike other PLC isotypes, the protein contain two src homology (SH) 2 domains and one SH3 domain between the X and Y catalytic domains, and these three domains have been implicated in the regulation of cellular proliferation and growth. The protein also has a key function in the regulation of growth hormone-mediated signalling by negatively regulating Jak2 activation. Human PLCgâ¡ gene maps to the chromosome 20 in the region 20q12-q13.1.
Catalog #136329
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:10,000
Western Blot: 1:500-1:1000
Immunohistochemistry (Paraffin): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human PLCG1.
SpecificityRecognizes human PLCG1. Species Crossreactivity: Mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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