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You are here:Home » Antibodies » Abs to Receptor Tyrosine Kinases » Anti -TrkA (Tyrosine Receptor Kinase A, Trk A, Trk-A, Neurotrophic Tyrosine Kinase Receptor Type 1, NTRK1, p140 TrkA, TRK1, TRK 1, TRK1 Transforming Tyrosine Kinase Protein)

Anti -TrkA (Tyrosine Receptor Kinase A, Trk A, Trk-A, Neurotrophic Tyrosine Kinase
Receptor Type 1, NTRK1, p140 TrkA, TRK1, TRK 1, TRK1 Transforming Tyrosine Kinase Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
NTRK1 (trkA), a Trk/Ror type protein kinase, is a high-affinity receptor for the nerve growth factor NGF. NTRK1 has been shown to regulate neural development and maintenance of neural network. Mutation in NTRK1 gene is responsible for congenital insensitivity to pain with anhidrosis (CIPA), an autosomal recessive hereditary disorder characterized by recurrent episodic fever, anhidrosis (inability to sweat), absence of reaction to noxious stimuli, self-mutilating behavior, and mental retardation. Rearrangements and fusion of NTRK1 gene to other genes have been implicated in colon and papillary thyroid cancers. Two protein isoforms have been identified.
Catalog #136495
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1000
Western Blot: 1:100-1:500
Immunohistochemistry (Paraffin): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to human NTRK1 at C-Terminal
conjugated to KLH.
SpecificityRecognizes human NTRK1. Species Crossreactivity: Mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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