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You are here:Home » Antibodies » Abs to Aquaporin » Anti -Aquaporin 4 (AQP4)

Anti -Aquaporin 4 (AQP4)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IF
Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 4 is constitutively expressed in the basolateral cell membrane of princinpal collecting duct cells in the kidney and provide a pathway for water to exit these cells (3). It is also expressed in astrocytes and is upregulated by direct insult to the CNS (4). Aquaporin 4 has been propsed as the primary autoimmune target in neuromyelitis optica ( 5, 6).
Catalog #136758
ApplicationsSuitable for use in Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:400
Western Blot: 1:1000-1:4000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceRat
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
PurityAffinity Purified
ImmunogenSequence N-CTKGSYMEVEDNRSQVETED (Rat)
SpecificityRecognizes rat Aquaporin 4 at ~35kD. May detect larger glycosylated band at ~50kD. Species Crossreactivity: Human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAQP4


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