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You are here:Home » Antibodies » Abs to Enzymes, Cyclase » Anti -Adenylate Cyclase Type 3 (Adenylate Cyclase Type III, AC-III, Adenylyl Cyclase 3, AC3, Adcy3, Adenylate Cyclase Olfactive Type, ATP Pyrophosphate-lyase 3)

Anti -Adenylate Cyclase Type 3 (Adenylate Cyclase Type III, AC-III, Adenylyl Cyclase 3,
AC3, Adcy3, Adenylate Cyclase Olfactive Type, ATP Pyrophosphate-lyase 3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH IC
Adenylate cyclases are enzymes which interact with and are activated by the GTP bound alpha subunits of trimeric G-proteins. Activated adenylate cyclases are responsible for the production of the important "second messenger" signalling molecule cyclic-AMP, which is generated from ATP. The type III adenylate cyclase enzyme is localized in the membranes surrounding the cilia in neurons.
Catalog #136860
Adenylate cyclase type III is a large complex molecule of, in the human, 1145aa with a deduced molecular weight of 129kD. The protein may be variably glycosylated, so that on SDS-PAGE and western blots it runs as a diffuse band of about 160kD in cortex and about 200kD in olfactory epithelium. The molecule has a complex structure, with 12 transmembrane domains and two cyclase domains. Each cyclase domain is immediately C-terminal to 6 transmembrane segments, but only the second, C-terminal cyclase is believed to be catalytically active.
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:500-1:1000
Western Blot: 1:10,000 (major bands at 160-200kD, depending on the tissue)
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
Concentration~1mg/ml
FormSupplied as a liquid.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to fusion protein containing the extreme C-terminal segment of rat NF-M.
SpecificityRecognizes rat ADCY3. Species Crossreactivity: feline, chicken, human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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