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You are here:Home » Antibodies » Abs to Hormones, Steroids » Anti -Cholecystokinin 8 (CCK8, CCK-8)

Anti -Cholecystokinin 8 (CCK8, CCK-8)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH IF
Cholecystokinin (CCK) is one of the most important hormone regulators of the digestive process. The peptide is concentrated in the proximal small intestine (CCK cells) and is secreted into the blood in response to the ingestion of proteins and fats, where its actions include the stimulation of pancreatic secretion, the modulation of insulin output, the regulation of gastric emptying, and gallbladder contraction. In the central nervous system CCKergic fibres are widespread, being particularly abundant in the cerebral cortex. In some mesolimbic neurons projecting to the nucleus accumbens, CCK is colocalised with dopamine and it has been suggested that CCK might facilitate the function of dopamine in events such as stimulusreward associative behaviour. Secretion of CCK from the murine tumour cell line STC1 has been shown to be stimulated by pituitary adenylate cyclase activating protein (PACAP) and has raised the possibility that PACAP may function as a neuromodulator of CCK release from gut endocrine cells in vivo. CCK-8 is also suspected to heighten pain sensation in diabetics.
Catalog #136883
ApplicationsSuitable for use in Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:100-1:200 (Fluorescein), 1:500-1:1000 (Streptavidin/HRP)
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
ConcentrationNot determined
FormSupplied as a lyophilized powder in 0.09% thyroglobulin (BTg), glutaraldehyde, sodium azide. Reconstitute with 100ul distilled or deionized dH2O.
PuritySerum
ImmunogenSulfated CCK-8 (aa26-33) coupled to bovine thyroglobulin (BTg) with glutaraldehyde.
SpecificityRecognizes CCK-8. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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