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You are here:Home » Growth Factors, Cytokines » Growth Factors-VEGF » EG-VEGF, Recombinant, Human (Prokineticin-1, Endocrine-gland-derived Vascular Endothelial Growth Factor, Mambakine, PROK1, UNQ600/PRO1186)

EG-VEGF, Recombinant, Human (Prokineticin-1, Endocrine-gland-derived Vascular Endothelial
Growth Factor, Mambakine, PROK1, UNQ600/PRO1186)

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Specifications

Recombinant Human Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-hVEGF) is selectively expressed in steroidogenic glands and promotes the growth of endocrine gland endothelium. The identification of tissue-selective angiogenic factors raises the possibility that other secreted molecules in this class exist. Consistent with such an expression pattern, the human EG-VEGF gene promoter has a potential binding site for steroidogenic factor-1, a pivotal element for steroidogenic-specific transcription. In the human ovary, the expression of EG-VEGF is temporally and spatially complementary to the expression of VEGF-A, both in the follicular and in the luteal phase, suggesting complementary and coordinated roles of these molecules in ovarian angiogenesis. Also, EG-VEGF expression correlates with vascularity in the polycystic ovary syndrome, a leading cause of infertility.
Catalog #136889
SourceRecombinant corresponding to human EG-VEGF, expressed in E.coli.
Molecular Weight~9.6kD
Biological ActivityDetermined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1-5ng/ml.
AA SequenceAVITGACERD VQCGAGTCCA ISLWLRGLRM CTPLGREGEE CHPGSHKVPF
FRKRKHHTCP CLPNLLCSRF PDGRYRCSMD LKNINF
Endotoxin ~0.01ng/ug (LAL)
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~9.6kD
SourceE.coli
Purity~97% (RP-HPLC)
Concentration~0.1mg/ml after reconstitution
FormSupplied as a lyophilized powder. Reconstitute with sterile water to 100ug/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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