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You are here:Home » Antibodies » Abs to Myelin » Anti -MBP (Myelin Basic Protein, Myelin A1 Protein, Myelin Membrane Encephalitogenic Protein)

Anti -MBP (Myelin Basic Protein, Myelin A1 Protein, Myelin Membrane Encephalitogenic
Protein)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Affinity Purified B IF
Myelin basic protein is reported to account for about 30 of the proteins in myelin found in the central nervous system. It can induce experimental allergic encephalomyelitis (EAE), a T-lymphocyte mediated disease due to delayed-type hypersensitivity; though each animal species appears to respond to a different fragment of the 170aa polypeptide. Four different isoforms have been identified through cDNA cloning. All four of these variants are identical except for the insertion or deletion of two peptide fragments encoded by exons 2 and 5. Myelin basic protein is reported to be expressed in oligodendrocytes, myelin of white matter in the brain and spinal cord and in peripheral nerves, though it is expressed less abundantly in gray matter.
Catalog #136926
MBP has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. In vitro, MBP is suitable as a substrate for numerous protein kinases, including the ERK and p38 MAP kinases that phosphorylate MBP at T98.
ApplicationsSuitable for use in Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:1000
Western Blot: 1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgY
HostChicken
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 10mM sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenMixture of 3 MBP peptides corresponding to the different forms of the protein which are alternate transcription from a single gene.
SpecificityRecognizes Myelin Basic Protein. Species Crossreactivity: human, rat, mouse and bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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