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You are here:Home » Antibodies » Abs to Myelin » Anti -Myelin Basic Protein (MBP, Myelin A1 Protein, Myelin Membrane Encephalitogenic Protein, MGC99675)

Anti -Myelin Basic Protein (MBP, Myelin A1 Protein, Myelin Membrane Encephalitogenic
Protein, MGC99675)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
Myelin basic protein is reported to account for about 30 of the proteins in myelin found in the central nervous system. It can induce experimental allergic encephalomyelitis (EAE), a T-lymphocyte mediated disease due to delayed-type hypersensitivity; though each animal species appears to respond to a different fragment of the 170aa polypeptide. Four different isoforms have been identified through cDNA cloning. All four of these variants are identical except for the insertion or deletion of two peptide fragments encoded by exons 2 and 5. Myelin basic protein is reported to be expressed in oligodendrocytes, myelin of white matter in the brain and spinal cord and in peripheral nerves, though it is expressed less abundantly in gray matter.
Catalog #136931
MBP has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. In vitro, MBP is suitable as a substrate for numerous protein kinases, including the ERK and p38 MAP kinases that phosphorylate MBP at T98.
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Paraffin-embedded and frozen tissue): 1:75-1:150 (High temperature antigen unmasking technique. 60min primary antibody incubation @ 25°C. Standard ABC technique.)
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No7H11
HostMouse
ConcentrationNot determined
FormSupplied as a liquid, 15mM sodium azide.
PuritySupernatant
ImmunogenPurified guinea pig myelin basic protein.
SpecificityRecognizes human Myelin Basic Protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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