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You are here:Home » Antibodies » Abs to Neurofilament » Anti -Neurofilament Heavy Polypeptide (NF-200, NF200, NF-H, NEFH, N52, Neurofilament Triplet H Protein, 200kD Neurofilament Protein, KIAA0845, NFH)

Anti -Neurofilament Heavy Polypeptide (NF-200, NF200, NF-H, NEFH, N52, Neurofilament
Triplet H Protein, 200kD Neurofilament Protein, KIAA0845, NFH)

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Serum IH IC
Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells. In the electron microscope neurofilaments appears as 10nm diameter fibres of indeterminate length which generally have fine wispy protrusions from their sides. They are found particularly abundantly in axons of large projection neurons. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons, and are biochemically very stable.
Catalog #136932
Some studies have shown that levels of neurofilament heavy and neurofilament light are elevated in patients with Alzheimer's disease, frontotemporal lobe dementia, and vascular dementia.
ApplicationsSuitable for use in Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: 1:1000-1:5000 using 2% paraformaldehyde-fixed tissues or cells
Immunocytochemistry: 1:5000-1:10,000 using 2% paraformaldehyde-fixed tissues or cells
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgY
HostChicken
ConcentrationNot Determined
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PuritySerum
ImmunogenBovine intermediate filaments (200kD) from spinal cords.
SpecificityRecognizes NF-H. Species Crossreactivity: human and mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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