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137023 CGB, Recombinant, Human, aa21-165, His-Tag (Choriogonadotropin Subunit Beta Precursor, CGB3, CGB5, CGB7, CGB8, hCGB) CAS:

Specifications
References
Grade
Purified
Molecular Weight
17.9
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

CGB is a member of the glycoprotein hormone beta chain family and is the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.

Source
Recombinant protein corresponding to human CGB, fused to His-tag at N-terminal expressed in E.coli.
Molecular Weight
~17.9kD (168aa)
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSSKEPLRP RCRPINATLA VEKEGCPVCI TVNTTICAGY CPTMTRVLQG VLPALPQVVC NYRDVRFESI RLPGCPRGVN PVVSYAVALS CQCALCRRST TDCGGPKDHP LTCDDPRFQD SSSSKAPPPS LPSPSRLPGP SDTPILPQ
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
≥85% (SDS-PAGE)
Concentration
~0.5mg/ml
Form
Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 0.4M urea, 10% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Andrusiewicz M, Szczerba A, et al. (2011). J Transl Med. 9:130. 2. Gregor CR, Cerasoli E, et al. (2011). J Biol Chem. 286(28):25016-26.
USBio References
No references available
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