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137301 Histone H4, Recombinant, Human, His-Tag (HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4F, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, HIST1H4H, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4) CAS:

Specifications
References
Grade
Purified
Swiss Prot
P62805
Accession Number
NM_003548
Molecular Weight
12.1
EU Commodity Code
30021019
Shipping Temp
Dry Ice
Storage Temp
-70°C

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Full-length recombinant protein corresponding to aa2-103 from human Histone 4, fused to His tag at N-terminal, expressed in E. coli. Genbank Accession Number: NM_003548
Molecular Weight
~12.1kD
Applications
Suitable for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Source
Recombinant, E. coli
Purity
≥80% (SDS-PAGE)
Concentration
As Reported
Form
Supplied as a liquid in 8mM PBS, pH 7.4, 110mM sodium chloride, 2.2mM potassium chloride, 3mM DTT, 20% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Kornberg, R.D. (1977) Annu. Rev. Biochem., 46, 931-954. 2. van Holde, K.E. (1989) Chromatin, 1-497.
USBio References
No references available
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