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You are here:Home » Molecular Biology » MB-Growth Factors-TGF » TGFb1, Latent, Recombinant, Human, His-Tag (Transforming Growth Factor Beta-1, TGF-beta-1, LAP, TGFB)

TGFb1, Latent, Recombinant, Human, His-Tag (Transforming Growth Factor Beta-1, TGF-beta-1,


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TGF beta is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. It plays an important role in bone remodeling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation, and differentiation in committed osteoblasts.
Catalog #137382
Recombinant protein corresponding to aa30-390 from human TGFb1 fused to His-tag at N-terminal and disulfide-linked homodimers of TGFb1 LAP and mature TGFb1 expressed in FreeStyle 293-F cells.
Molecular Weight~75kD and ~25kD under non-reducing conditions
Biological ActivityMeasured by TGFb1's ability to inhibit mIL-4-dependent proliferation of HT-2 mouse helper T cells. The ED50 is <0.5ng/ml.
ApplicationsSuitable for use in cell cultures and for the study of signaling and apoptotic pathways. Other applicaions not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -70°C. Stable for 12 months after receipt at -70°C. Reconstitute with sterile PBS, 0.1% BSA. Aliquot to avoid repeated freezing and thawing. Store at -70°C. Reconstituted product is stable for 6 months at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~75kD, 25kD
SourceFreeStyle 293-F cells
PurityPurified (~98%)
ConcentrationNot determined
FormSupplied as a lyophilized powder from a 0.2um filtered, aqueous solution. Reconstitute with sterile PBS, 0.1% BSA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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