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You are here:Home » Antibodies » Abs to Receptors » Anti -Adrenergic Receptor, Beta 1 (B1AR, B1-Adrenergic Receptor)

Anti -Adrenergic Receptor, Beta 1 (B1AR, B1-Adrenergic Receptor)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
B1--Adrenergic Receptor (B1AR) is a G protein-coupled receptor (GPCR) involved in the regulation of cardiovascular functions (1). Together with B2AR, B1AR is a major BAR in the heart. B1AR is activated by catecholamines and couples to Gas protein, activating adenylate cyclase and increasing intracellular cAMP levels (2). Beta-blockers (BAR antagonists), one of the major class of therapeutics in cardiovascular medicine, act mostly by preventing catecholamine binding to B1AR (3).
Catalog #137406
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000. Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied in 10mM sodium HEPES, pH 7.5, 150mM NaCl, 100ug/ml BSA and 50% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to residues surrounding Gly406 of human B1-Adrenergic Receptor. Species Sequence Homology: monkey
SpecificityRecognizes endogenous levels of total human B1-Adrenergic Receptor protein. Species Crossreactivity: mouse, rat. Does not cross-react with B2-Adrenergic Receptor.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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