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You are here:Home » Molecular Biology » MB-Growth Factors-Interleukin » IL-33, Recombinant, Mouse, His-Tag (Interleukin-33, His6IL-33) (Carrier free)

IL-33, Recombinant, Mouse, His-Tag (Interleukin-33, His6IL-33) (Carrier free)


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IL-33 is a novel member of the IL-1 family of proteins that was discovered in a computational search to identify unknown family members (1). IL-33 is expressed by fibroblasts and endothelial cells, and is upregulated in response to inflammatory stimuli (1). IL-33 plays a key role in Th2 type inflammatory responses, including atopic allergic responses and asthma (1,2). The IL-33 receptor consists of the ST2 and IL-1 accessory protein (IL-1-Acp) (1,3). ST2 is expressed on mast cells, basophils and Th2 cells (1). In addition to its putative role as a Th2 cytokine, IL-33 also contains a nuclear localization domain and may function as a nuclear factor (4,5). The nuclear function of IL-33 remains unclear. IL-33 is released by cellular necrosis, similar to other “alarmins”, thereby signaling tissue injury (5,6). However, more recent data suggests that IL-33 may also be actively secreted from live cells via a non-classical mechanism (7).
Catalog #137449
SourceRecombinant protein corresponding to mouse His6IL-33, fused to His-tag expressed in E. coli.
Molecular Weight~22kD
Biological ActivityDetermined by its ability to induce IL-13 production by MC/9 cells. The ED50/lot is 1-6ng/ml.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~22kD
SourceE. coli
Purity~98% (SDS-PAGE)
Concentration~0.1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder in PBS, pH 7.2, 1mM EDTA, 3mM DTT. Reconstitute in sterile PBS.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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