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You are here:Home » Molecular Biology » Growth Factors-Interleukin » IL18BP, Recombinant, Human, aa31-194, His-Tag (Interleukin-18-binding Protein, IL18BPa)

IL18BP, Recombinant, Human, aa31-194, His-Tag (Interleukin-18-binding Protein, IL18BPa)

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Specifications

IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease.
Catalog #138669
SourceRecombinant protein corresponding to aa31-194 from human IL18BP at N-terminal, fused to His-tag expressed in E.coli.
Molecular Weight~20.0kD (187aa)
AA SequenceMGSSHHHHHH SSGLVPRGSH MGSTPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVP LNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTN FSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSH
SSPQQQG
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~20.0kD
SourceE. coli
Purity~90% (SDS-PAGE)
Concentration~1mg/ml
FormSupplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.4M urea, 10% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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