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You are here:Home » Growth Factors, Cytokines » Growth Factors-Activin, Inhibin » Activin A, Recombinant, Mouse (Inhibin Beta-1, FRP, FSH-releasing Protein)

Activin A, Recombinant, Mouse (Inhibin Beta-1, FRP, FSH-releasing Protein)

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Specifications

Activin A is a member of the TGFbeta family of proteins produced by many cell types throughout development. Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, metabolism, etc. Activin A is a homodimer of two beta A chains and is not biologically active until the N-terminal propeptide is cleaved from each. Mouse Activin A has 100% amino acid sequence identity to human, rat, porcine, bovine and feline proteins.
Catalog #142844
SourceRecombinant protein corresponding to two 117aa chains from mouse Activin A expressed in E.coli.
Molecular Weight~26.2kD
Endotoxin 1EU/ug (LAL)
Biological ActivityRecombinant mouse Activin A has full biological activity when compared to a standard. The ED50 as determined by the the ability to induce cytotoxicity MPC-11 cells is 1-1.5ng/ml.
Amino Acid SequenceMGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, aliquot and store at -20°C. It is recommended for long-term storage to add a carrier protein 0.1% HSA or BSA. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~26.2kD
SourceE.coli
Purity~95% (HPLC, Reducing and non-reducing SDS-PAGE)
FormSupplied as a lyophilized powder, 0.02% TFA. Reconstitute with sterile ddH2O. For long term storage, add a carrier protein (0.1% HSA or BSA).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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