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You are here:Home » Molecular Biology » MB-Tyrosine Kinases » Flt-3 Ligand, Recombinant, Human, Animal Free (FLT-3-Ligand, FMS-related Tyrosine Kinase 3 Ligand, AF, FLt3 L, Fms-related Tyrosine Kinase 3 Ligand)

Flt-3 Ligand, Recombinant, Human, Animal Free (FLT-3-Ligand, FMS-related Tyrosine Kinase 3
Ligand, AF, FLt3 L, Fms-related Tyrosine Kinase 3 Ligand)

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Specifications

FMS-related Tyrosine Kinase 3 Ligand (FLT-3 Ligand) is a growth factor important for the proliferation of hematopoietic cells. FLT- 3 Ligand binds to, and transmits signals through, the receptor tyrosine kinase known as FMS-like Tyrosine Kinase-3 (FLT-3). FLT-3 Ligand promotes long-term expansion and differentiation of human pro-B cells in the presence of IL-7 or in combination of IL-7 and IL-3. Human FLT-3 Ligand can stimulate the proliferation of cells expressing murine FLT-3 receptors. R
Catalog #142873
SourceRecombinant protein corresponding to 155a from human FLT-3 Ligand expressed in E.coli.
Molecular Weight~17.6kD
Endotoxin 1EU/ug (LAL)
Biological ActivityThe activity is determined by the dose-dependent production of IL-6 by human PBMCs and is typically 100-200ng/ml
AA SequenceMTQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPT
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~17.6kD
SourceE.coli
Purity~98% (HPLC, Reducing and non-reducing SDS-PAGE)
FormSupplied as a lyophilized powder in 10mM Na2PO4, pH 7.5. Reconstitute with sterile dH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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