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You are here:Home » Molecular Biology » Growth Factors-GDF » GDF-15, Recombinant, Human (Growth and Differentiation Factor-15, D Variant, GDF-15-D, MIC-1, Placental TGFbeta, Prostate, Differentiation Factor)

GDF-15, Recombinant, Human (Growth and Differentiation Factor-15, D Variant, GDF-15-D,
MIC-1, Placental TGFbeta, Prostate, Differentiation Factor)

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Specifications

Growth and Differentiation Factor 15 (GDF-15) is a TGFb family member, made by the placenta and heart tissues, that has a role in regulating inflammatory and apoptotic pathways. GDF-15 has become an immerging marker of early heart disease and has the potential as being used as a molecule for screening patients for early heart failure.
Catalog #142878
SourceRecombinant protein corresponding to two identical 120aa chains from human GDF-15 expressed in E.coli.
Molecular Weight~26.8kD
Endotoxin 1EU/ug (LAL)
Biological ActivityThe activity is determined by the inhibition of DU-145 cells and is typically 1-2ug/ml.
AA SequenceMARNGDDCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~26.8kD
SourceE.coli
Purity~95% (HPLC, Reducing and non-reducing SDS-PAGE)
FormSupplied as a lyophilized powder. No additives. Reconstitute with sterile 5mM acetic acid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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