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You are here:Home » Growth Factors, Cytokines » Growth Factors-IGF » IGF-I, Recombinant, Human, Animal Free (Insulin-like Growth Factor I, AF, Somatamedin C, Mechano Growth Factor, IGF-IA)

IGF-I, Recombinant, Human, Animal Free (Insulin-like Growth Factor I, AF, Somatamedin C,
Mechano Growth Factor, IGF-IA)

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Specifications

Insulin-like Growth Factor I, IGF-I, is a growth factor produced by the liver when stimulated with growth hormone and can be found circulating throughout the body . IGF-I activates the IGF-I receptor (IGF1R) and the insulin receptor to mediate growth of almost every cell of the body. IGF-I is known as one of the most potent activators of the AKT signaling pathway which is known to be a stimulator of proliferation and an inhibitor of programmed cell death. Mature human IGF-I is 100% homologous with bovine and porcine proteins.
Catalog #142887
SourceRecombinant protein corresponding to 70aa from human IGF-I, expressed in E.coli.
Molecular Weight~7.7kD
Endotoxin 1EU/ug (LAL)
Biological ActivityThe activity is determined by the dose-dependent proliferation of mouse FDC-P1 cells is typically <1.0ng/ml
AA SequenceGPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~7.7kD
SourceE.coli
Purity~98% (HPLC, Reducing and non-reducing SDS-PAGE)
FormSupplied as a lyophilized powder. No additives. Reconstitute with sterile dH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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