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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » Interleukin-1-beta, Recombinant, Human (IL-1 Beta, Catabolin, LAF, EP, LEM, MCF)

Interleukin-1-beta, Recombinant, Human (IL-1 Beta, Catabolin, LAF, EP, LEM, MCF)

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Specifications

Interleukin-1 beta (IL-1b) is a pro-inflammatory cytokine produced in response to inflammatory agents by a variety of cells, including monocytes, macrophages, and dendritic cells (DCs). IL-1b and IL-1a are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1a is cell associated and IL-Ib is secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock. Signaling activated by the IL-1R1 promotes these activities through a MYD88 signaling pathway similar to those associated with Toll receptors.
Catalog #142888
SourceRecombinant protein corresponding to 153aa from human IL-1b expressed in E.coli.
Molecular Weight~17.4 kD
Endotoxin 1EU/ug (LAL)
Biological ActivityThe activity is determined by the stimulation of D10S.G4.1 cells and is typically <12pg/ml.
AA SequenceAPVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer
Molecular Weight~17.4 kD
SourceE.coli
Purity~97% (HPLC, Reducing and non-reducing SDS-PAGE)
FormSupplied as a lyophilized powder in 10mM Na2PO4, pH 7.5. Reconstitute with sterile dH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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