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You are here:Home » Antibodies » Abs to Interleukin » Anti -Interleukin 17A (IL-17A, CTLA-8)

Anti -Interleukin 17A (IL-17A, CTLA-8)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B
nterleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL- 17A-17F). IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. Human, mouse and rat IL-17A show activity on mouse cells. Human IL-17A is disulfide-linked, homodimer consisting of two 137 amino acid proteins and having a total molecular mass of 31kD (without gylcosylation).
Catalog #142897
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Endotoxin<0.1EUs/ug
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2. No preservatives or stabilizers added.
PurityPurified Ig fraction
ImmunogenFull length recombinant protein corresponding to human IL-17A.
SpecificityRecognizes human IL-17A
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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