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You are here:Home » Antibodies » Abs to Interleukin » Anti -Interleukin 17A (IL-17A, CTLA-8)

Anti -Interleukin 17A (IL-17A, CTLA-8)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Purified E B FC
Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL- 17A-17F). IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis.
Catalog #142899
ApplicationsSuitable for use in Flow Cytometry, ELISA, Western Blot. Other applications not tested.
Recommended DilutionFlow Cytometry: 0.1ug/ml starting dilution
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Endotoxin<0.1EUs/ug
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No20B4
HostRat
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2. No preservatives or stabilizers added.
PurityPurified
ImmunogenFull length recombinant protein corresponding to mouse IL-17A.
SpecificityRecognizes mouse IL-17A. Human, mouse and rat IL-17A show activity on mouse cells.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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