Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » Interleukin 1alpha, Recombinant, Human (IL-1 alpha, IL-1F1, FAF, BAF, LEM, LAF)

Interleukin 1alpha, Recombinant, Human (IL-1 alpha, IL-1F1, FAF, BAF, LEM, LAF)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Interleukin-1 alpha (IL-1a) is constiutively expressed by epithlial cells, but can also be produced by most other cells upon stimulation. IL-1a and IL-1a are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1a is cell associated and IL-1bis secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock. Signaling activated by the IL-1R1 promotes these activities through a MYD88 signaling pathway similar to those associated with Toll receptors.
Catalog #142917
SourceRecombinant protein corresponding to 159aa from human IL-1a expressed in E.coli.
Molecular Weight~18kD
Endotoxin 1EU/ug (LAL)
Biological ActivityThe activity is determined by the stimulation of D10S.G4.1 cells and is typically 1-6pg/ml.
AA SequenceSAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKYQLY VTAQDEDQPV LLKEMPEKPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~18kD
SourceE.coli
Purity~97% (HPLC, Reducing and non-reducing SDS-PAGE)
FormSupplied as a lyophilized powder. No additives. Reconstitute with sterile dH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links